Воздействие регулярных физических нагрузок на физико–химические свойства мембран эритроцитов. 165. кислородпереносящих систем крови, одним из лимитирующих факторов которых является мембрана эритроцита.


Чтобы посмотреть этот PDF файл с форматированием и разметкой, скачайте файл и откройте на своем компьютере.
165 G_^hklZldZfb f_lh^Z y\eyxlky : hlghkbl_evgZy keh`ghklv mklZgh\db kl_glZ ( hkh[_ggh ^eb - l_evgh]h klhygby ), qlh \ bkdexqbl_evguo kemqZyo lj_[m_l ijh\_^_gby ijhp_^mju ih^ j_gl]_gl_ - e_\babhgguf dhgljhe_f , \hafh`ghklv jZa\blby \ g_dhlhjuo kemqZyo imaujgh ihq_qguo j_nexd - kh\ b ^bamjbq_kdbo jZkkljhckl\ , g_\hafh`ghklv dhgljhey aZ jZ[hlhc kl_glZ , ljm^ghklv aZf_gu . Ihq_qguc kl_gl ^he`_g h[eZ^Zlv : x Ijhqghklvx b weZklbqghklvx x ukhdhc ijhdkbfZevghc kbehc , ij_^hl\jZsZxs_c _]h fb]jZpbx x Gbadbf dhwnnbpb_glhf lj_gby x hafh`ghklvx gZoh`^_gby \ aZ^Zgghc ihabpbb ^ebl_evgh_ \j_fy . x ;bheh]bq_kdhc ijhqghklvx ( mklhcqb\hklv d Z^khj[pbb djbklZeeh\ khe_c , [Zdl_jbc b ijhl_bgh\ gZ ih\_joghklb ) x Ijhlb\hj_nexdkghc aZsblhc beb fbgbfZevgufb Zglbj_nexdkgufb ijhy\e_gby - fb , qlh[u g_ gZjmrZlv _kl_kl\_ggmx i_jbklZevlbdm fhq_lhqgbdZ . x Kihkh[ghklvx e_]dh mklZgZ\eb\Zlvky Ihke_ mklZgh\db kl_glZ g_h[oh^bfh : x MklZgh\blv dZl_l_j Nhe_y \ fhq_\hc imaujv gZ 23 kmlhd x Ijh\_klb bgl_gkb\gmx l_jZiby k jZpbhgZevguf ijbf_g_gb_f Zglb[bhlbdh\ , mjh - Zglbk_ilbdh\ . x uihegblv ihk_\ fhqb gZ nehjm b qm\kl\bl_evghklv d Zglb[bhlbdZf . 3) Ijb [_amki_rguo ihiuldZo mklZgh\db fhq_lhqgbdh\uo dZl_l_jh\ beb kl_glh\ \hagbdZ_l g_h[oh^bfhklv hl\_^_gby fhqb iml_f imgdpbhgghc g_njhklhfbb . H^gZdh wlhl f_lh^ ijb \k_o k\hbo ^hklhbgkl\Zo bf__l jy^ g_^hklZldh\ . 1. Ljm^ghklv mklZgh\db imgdpbhgghc g_njhklhfu m [_j_f_gguo ( iheh`_gb_ iZpb_gldb gZ [hdm , g_\hafh`ghklv beb djZcgyy h]jZgbq_gghklv j_gl]_gh\kdh]h dhgljhey ) 2. ukhdbc jbkd dZl_l_j Zkkhpbbjh\Zgghc bgn_dpbb 3. agZqbl_evgh_ mom^r_gb_ dZq_kl\Z `bagb iZpb_gldb k g_njhklhfhc b \ukhdbc jbkd kem - qZcgh]h hloh`^_gby ^j_gZ`Z . k_ i_j_qbke_ggu_ f_lh^bdb ^j_gbjh\Zgby fhq_\uo iml_c \ ih^Z\eyxs_f [hevrbgkl\_ kem - qZ_\ iha\heyxl ba[_`Zlv ijh\_^_gby hldjuluo hi_jZlb\guo \f_rZl_evkl\ , dhlhju_ y\eyxlky \ukhdhljZ\fZlbqgufb b hiZkgufb ^ey `bagb b a^hjh\vy , dZd iZpb_gldb , lZd b ieh^Z . Ebl_jZlmjZ 1. :ey_\ , X . = ., =Zabfh\ F . : ., ?gbd__\ � .  . Kh\j_f_ggu_ Zki_dlu ^bZ]ghklbdb b e_q_gby ]_klZpbhggh]h ib_ehg_njblZ ./ Mjheh]by 2008,  1, k . 36 2. FbjaZeb_\ W . D ., A_gdh\ K . K ., AgZq_gb_ \u[hjZ ^hklmiZ \ ijhnbeZdlbd_ hkeh`g_gbc q_j_adh`ghc imgdpbhgghc g_njhklhfbb / Mjheh]by 2008,  4, k . 6670 3. JZnZevkdbc ,  .  ., Qbeh\Z J . : ., Hkljhmoh\Z F .  . F_klh kh\j_f_gguo eZdlZfguo Zglb[bhlbdh\ \ l_ - jZibb bgn_dpbb fhq_\u\h^ysbo iml_c m [_j_f_gguo ,/ Mjheh]by 2009,  5, k . 1418 166 dbkehjh^i_j_ghkysbo kbkl_f djh\b , h^gbf ba ebfblbjmxsbo nZdlhjh\ dhlhjuo y\ey_lky f_f[jZgZ wjbljhpblZ . Kh]eZkgh [1], f_f[jZggu_ kljmdlmju kihkh[gu j_]mebjh\Zlv Zdlb\ghklv bgl_]jZevguo [_edh\ i_j_ghkqbdh\ , \ lhf qbke_ b Zd\Zihjbgh\ , dhlhju_ \uihegyxl hkgh\gmx jhev ijb i_j_ghk_ dbkehjh^Z q_j_a f_f[jZgm wjbljhpblZ [2]. LZd dZd f_f[jZggu_ ebib^u y\eyxlky h^gbf ba dhfihg_glh\ Z^ZilZpbhgguo kbkl_f q_eh\_dZ [3], ke_^m_l h`b^Zlv baf_g_gb_ nbabdh obfbq_kdbo k\hckl\ f_f[jZg wjbljhpblh\ ih^ \ha^_ckl\b_f j_]meyjguo nbabq_kdbo gZ]jmahd . Ihfbfh wlh]h , fhgblhjbg] dexq_\uo iZjZf_ljh\ , ij_l_ji_\Zxsbo baf_g_gb_ \ mkeh\byo ihklhygguo lj_gbjh\hd , fh`_l iha\heblv jZajZ[hldm f_lh^h\ bo dhjj_dpbb ^ey m\_ebq_gby Z^ZilZpbhgguo kihkh[ghkl_c hj]ZgbafZ ihkj_^kl\hf fh^bnbdZpbb nbabdh obfbq_kdh]h khklZ\Z f_f[jZg wjbljhpblh\ .  k\yab k wlbf p_evx gZr_]h bkke_^h\Zgby [ueh \uy\e_gb_ hlebqbc nbabdh obfbq_kdbo k\hckl\ f_f[jZg wjbljhpblh\ kihjlkf_gh\ b ebp , g_ aZgbfZxsboky kihjlhf dZd h^gh]h ba dexq_\uo iZjZf_ljh\ ]hlh\ghklb d ih\ur_gguf nbabq_kdbf gZ]jmadZf . FZl_jbZeu b f_lh^u bkke_^h\Zgbc �ey bamq_gby \ha^_ckl\by nbabq_kdbo gZ]jmahd [ueh knhjfbjh\Zgu hiulgZy ]jmiiZ ba 27 q_eh\_d h[h_]h iheZ , bf_xsbo mjh\_gv kihjlb\ghc d\ZebnbdZpbb hl 1 ]h \ajhkeh]h jZajy^Z ^h fZkl_jZ kihjlZ b dhgljhevgZy ]jmiiZ ba 36 q_eh\_d h[h_]h iheZ , g_ aZgbfZxsb_ky j_]meyjgufb nbabq_kdbfb gZ]jmadZfb . �ey bkke_^h\Zgby nbabdh obfbq_kdbo k\hckl\ f_f[jZg wjbljhpblh\ m ebp hiulghc b dhgljhevghc ]jmii ijhba\h^beky aZ[hj djh\b \ \Zdmmf ijh[bjdb k pbljZlhf gZljby . F_f[jZgu wjbljhpblh\ ihemqZeb ih f_lh^m �h^`Z [4] gZ p_gljbnm]_ Thermo Scientific Heraeus Biofuge Stratos, BlZeby . Kmki_gabx f_f[jZg klZg^Zjlbah\Zeb ih [_edm ^h 100 fd] / fe b lbljh\Zeb 2 fF jZkl\hjhf ibj_gZ \ dhgp_gljZpbyo 1, 2, 4, 6, 8 b 10 fdfhev / fe . H^gh\j_f_ggh kgbfZebkv ki_dlju nemhj_kp_gpbb ijb ^ebgZo \heg 286 b 337 gf gZ ki_dljhnemhjbf_lj_ Solar CM2203 ( ;_eZjmkv ). Ih khhlghr_gbx \ukhlu ibdh\ nemhj_kp_gpbb ijb  j_] = 470480 gf b ijb  j_] = 374376 gf , km^beb h fbdjh\yadhklb f_f[jZg wjbljhpblh\ , iheyjghklv [_edh\h]h fbdjhhdjm`_gby hij_^_eyeZkv ih khhlghr_gbx ibdh\ ijb  j_] = 470480 gf b ijb  j_] = 380400 gf [5]. �ey hij_^_e_gby ijh]ghaghc agZqbfhklb nbabdh obfbq_kdbo k\hckl\ f_f[jZg wjbljhpblh\ bkihevah\Zeky y^_jguc gZb\guc [Zc_kh\kdbc deZkkbnbdZlhj k iheguf f_lh^hf hp_gdb b nbdkbjh\Zgghc ijhimkdghc kihkh[ghklvx . JZkq_lu \uihegyebkv \ iZd_l_ bgl_ee_dlmZevgh]h ZgZebaZ ^Zgguo RapidMiner 5.2. J_amevlZlu b bo h[km`^_gb_ Hp_gdZ fZljbpu khijy`_gghklb ( lZ[ebpZ 1) ijh]ghabjm_fh]h ( gZ hkgh\Zgbb bkke_^m_fuo ihdZaZl_e_c ) j_amevlZlZ k j_Zevgh bf_xsbfky , ijh^_fhgkljbjh\ZeZ gb`_ke_^mxs__ : LZ[ebpZ FZljbpZ khijy`_gghklb deZkkbnbdZlhjZ ^ey hiulghc b dhgljhevghc ]jmii Ijh]gha 1 uc \ajhkeuc jZajy^ DZg^b^Zl \ fZkl_jZ kihjlZ FZkl_j kihjlZ DhgljhevgZy ]jmiiZ Lhqghklv ijh]ghaZ 1 uc \ajhkeuc jZajy^ 3 0 0 0 100.00% DZg^b^Zl \ fZkl_ - jZ kihjlZ 0 8 0 0 100.00% FZkl_j kihjlZ 0 0 15 2 88.24% DhgljhevgZy ]jmiiZ 0 0 1 34 97.14% o Lhqghklv deZkkbnbdZpbb 95,24% o Hrb[dZ deZkkbnbdZpbb 4,76% o Dhwnnbpb_gl jZg]h\hc dhjj_eypbb Kibjf_gZ 0,94 LZdbf h[jZahf , \u[jZggu_ ^ey deZkkbnbdZpbb ihdZaZl_eb ( nbabdh obfbq_kdb_ k\hckl\Z f_f[jZg wjbljhpblh\ ) k \ukhdhc kl_i_gvx ^hklh\_jghklb iha\heyxl hlg_klb bo ghkbl_ey d ]jmii_ kihjlkf_gh\ beb ebp , g_ aZgbfZxsboky kihjlhf . f_kl_ k l_f , deZkkbnbdZlhj g_\_jgh hlg_k h^gh]h ba kihjlkf_gh\ , bf_xsbo d\ZebnbdZpbx 167 fZkl_jZ kihjlZ \ deZkk g_ aZgbfZxsboky kihjlhf b 2 q_eh\_dZ ba dhgljhevghc ]jmiiu , [ueb g_\_jgh hlg_k_gu d fZkl_jZf kihjlZ . LZdZy g_lhqghklv fh`_l [ulv h[mkeh\e_gZ khklhygb_f kbkl_fu ljZgkihjlZ dbkehjh^Z \ fhf_gl aZ[hjZ djh\b h[ke_^h\Zgguo ex^_c . hafh`gh , hrb[hqgh hlg_k_gguc d g_ aZgbfZxsbfky kihjlhf fZkl_j kihjlZ \ fhf_gl aZ[hjZ djh\b bf_e g_ kZfu_ \ukhdb_ ihdZaZl_eb lj_gbjh\Zgghklb , Z ebpZ g_ aZgbfZxsb_ky kihjlhf fh]eb bf_lv ]_g_lbq_kdmx ij_^jZkiheh`_gghklv d \ukhdbf nbabq_kdbf gZ]jmadZf , eb[h Zdlb\gh aZgbfZebkv bghc nbabq_kdhc ^_yl_evghklvx .  p_eyo ^Zevg_cr_]h kh\_jr_gkl\h\Zgby ij_^eZ]Z_fhc deZkkbnbdZpbb g_h[oh^bfh [he__ lhqgh hljZ[hlZlv djbl_jbb nhjfbjh\Zgby bkke_^h\Zl_evkdbo b dhgljhevguo ]jmii , qlh ij_^iheZ]Z_lky k^_eZlv \ gZrbo ^Zevg_crbo bkke_^h\Zgbyo . u\h^u 1. Nbabdh obfbq_kdb_ k\hckl\Z f_f[jZg kihkh[gu \uklmiZlv \ dZq_kl\_ ij_^bdlhjZ hlg_k_gby d ]jmiiZf kihjlkf_gh\ beb ebp , g_ aZgbfZxsboky kihjlhf ijb bkihevah\Zgbb y^_jgh]h gZb\gh]h [Zc_kh\kdh]h deZkkbnbdZlhjZ . 2. Hrb[hqgh_ hlg_k_gb_ d ijhlb\hiheh`ghc ]jmii_ fh`_l [ulv h[mkeh\e_gh g_mql_ggufb \ wdki_jbf_gl_ nZdlhjZfb b lj_[m_l ^Zevg_cr_]h mlhqg_gby b jZajZ[hldb . Ebl_jZlmjZ 1. Lee, A.G. Lipidprotein interactions in biological membranes: a structural perspective / A.G. Lee // 2. Lblh\_p , W . I . Bkke_^h\Zgb_ f_oZgbafh\ dbkehjh^gh]h h[f_gZ wjbljhpblh\ q_eh\_dZ / W . I . Lblh\_p , E . I . IZjoZq , L . K . Kl_iZgh\Z [ b ^j .] // ;bhnbabdZ . L . 10. 2009. k . 425441. 3. Dj_ik , ? . F . Ebib^u de_lhqguo f_f[jZg : w\hexpby ebib^h\ fha]Z . :^ZilZp . Nmgdpby ebib^h\ / ? . F . Dj_ik . E .: GZmdZ , E_gbg]j . Hl^ gb_ , 1981. 339 k . 4. Dodge, J. The preparation and chem ical characteristics of hemoglobin free ghosts of erythrocytes / J. Dodge, C. Mitchell, D. Hanahan // Arch. Biochem. Biophys. 1963. Vol. 100, N 1. P. 119130. 5. �h[j_ph\ , = . ? . nemhj_kp_glgu_ ahg^u \ bkke_^h\Zgbb de_lhd , f_f[jZg b ebihijhl_bgh\ / = . ? . �h[j_ph\ . F .: GZmdZ , 1989. 277 k . �MD 639.1.091 E?Q?GB? IHKLLJ:F:LBQ?KDHC OH�GJHI:LBB DHE?GGH=H KMKL:: : :G:EBA J?AMEVL:LH IJBF?G?GBY H;H=:S?GGHC LJHF;HPBL:FB IE:AFU : . G . FZkludh\ ,  . I . �_cdZeh , D . ; . ;heh[hrdh bl_[kdbc ]hkm^Zjkl\_gguc f_^bpbgkdbc mgb\_jkbl_l \_^_gb_ . IhklljZ\fZlbq_kdZyohg^jhiZlby ( ohg^jhfZeypby ) oZjZdl_jbam_lky gZebqb_f jZa - ebqguo ih ]em[bg_ , ehdZebaZpbb b iehsZ^b ^_n_dlh\ ]bZebgh\h]h ojysZ m iZpb_glh\ , i_j_g_k - rbo ljZ\fm dhe_ggh]h kmklZ\Z . QZklhlZ \klj_qZ_fhklb ^Zgghc iZlheh]bb \Zjvbjm_l hl 51 ^h 66% ih ^Zgguf Zjljhkdhibb [1, 2 ]. =bZebgh\uc ojys h[eZ^Z_l mgbdZevgufb [bhf_oZgbq_kdbfb k\hckl\Zfb b kihkh[_g ijhlb\h - klhylv agZqbl_evguf f_oZgbq_kdbf gZ]jmadZf , \hagbdZxsbf \h \j_fy ^\b`_gbc [3]. H^gZdh ijb ih\j_`^_gbb hg bf__l djZcg_ h]jZgbq_gguc ihl_gpbZe d kihglZgghc j_]_g_jZpbb . Wlh k\yaZgh k gbadhc kihkh[ghklvx ohg^jhpblh\ d ijhebn_jZpbb , g_^hklZlhqghc bo fh[bevghklvx b hlkml - kl\b_f \ZkdmeyjbaZpbb f_`de_lhqgh]h fZljbdkZ [4]. LZd dZd ^Z`_ g_[hevrb_ ih iehsZ^b ^_n_dlu kmklZ\gh]h ojysZ kihkh[gu \uau\Zlv klhcdh_ h]jZgbq_gb_ nmgdpbb dhe_ggh]h kmklZ\Z , bg^mpb - jh\Zlv jZgg__ jZa\blb_ b ijh]j_kkbjh\Zgb_ ]hgZjljhaZ [5, 6], e_q_gb_iZpb_glh\kihklljZ\fZlbq_ - kdhcohg^jhiZlb_cy\ey_lkyZdlmZev ghcijh[e_fhckh\j_f_gghcljZ\fZlhe h]bbbhjlhi_^bb .  dhfie_dkghf e_q_gbb ^_n_dlh\ ojysZ hkh[h_ f_klh aZgbfZxl objmj]bq_kdb_ f_lh^u [7]. Kj_^b gbo rbjhdh ijbf_gyxl hi_jZlb\gu_ f_lh^bdb , gZijZ\e_ggu_ gZ klbfmeypbx j_iZjZlb\ - guo ijhp_kkh\ aZ kq_l de_lhd dhklgh]h fha]Z km[ohg^jZevgh]h kehy . Hgb ij_^mkfZljb\Zxl Zgl_ - ]jZ^gmx b j_ljh]jZ^gmxlmgg_ebaZpbxkm[ohg^jZevghc dhklb , fbdjhnjZdlmjbjh\Zgb_ , ^_[jb^` - f_gl . LZd`_ ijbf_gyxlky jZaebqgu_ \b^u hkl_hohg^jZevghc ZmlhljZgkieZglZpbb b ljZgkieZg - lZpbb Zmlh]_gguo ohg^jhpblh\ ^ey aZf_s_gby ^_n_dlh\ kmklZ\gh]h ojysZ . H^gZdh , \ [hevrbg - kl\_ kemqZ_\ , \gh\v h[jZah\ZggZy ldZgv ghkbl oZjZdl_j nb[jhojysZ beb nb[jhaghc ldZgb , dhlhjZy agZqbl_evgh hlebqZ_lky hl ghjfZevghc ojys_\hc b g_ kihkh[gZ iheghp_ggh \uihegylv __ nmgd -

Приложенные файлы

  • pdf 44249226
    Размер файла: 238 kB Загрузок: 0

Добавить комментарий